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F30204C-D2-10 F30204B-D-28Doxoves - STEALTH Liposomal Doxorubicin HCl (4.0mg/mL) pDoxoves - PEGylated Liposomal Doxorubicin HCl Doxorubicin HCl is loaded into PEGylated liposomes composed of HSPC/CHOL/mPEG2000-DSPE (56.2:38.5:5.3 mol/mol) with ammonium gradient by the active loading approach. It is comparable to the commercial product DOXIL. Lipid composition: HSPC/CHOL/mPEG2000-DSPE (56.2:38.5:5.3 mol/mol) Lipid concentration: 40.0 mM Doxorubicin HCl: 4.0 mg/mL Encapsulation efficiency: > 95% (typically 98%) Loading battery: 250 mM ammonium sulfate Mean particle size: 85 nm (80 - 90 nm) External solution: 10% sucrose, 10 mM histidine, pH 6.5 Shelf-life: 6 months, storage: 2-8 degree C F30204B-D-10 F30204C-D-22Combo kit of Doxoves and plain control liposomesCombo Kit of Doxoves And Plain Control Liposomes This combo kit composed of one vial of Doxoves (F30204B-D) and one vial of the plain ammonium sulfate control liposomes (F30204B-C) F30204C-D-10 F30204B-C-2%Control liposomes for Doxoves (40mM)Plain Control Liposomes for Doxoves Lipid composition: HSPC/CHOL/mPEG2000-DSPE (56.2:38.5:5.3 mol/mol) Lipid concentration: 40 mM Dox HCl concentration: none Loading battery: 250 mM ammonium sulfate Mean particle size: 85 nm (80-90 nm) External solution: 10% sucrose, 10 mM histidine, pH 6.0 - 6.5 Storage and Stability: stable for 6 months when stored in refrigerator (2-8 degree C) F30204B-C-10 F30204-IT-26STEALTH Liposomal Irinotecan HCl (2.0mg/mL, 80-100nm) }PEGylated Liposomal Irinotecan HCl Lipid composition: HSPC/CHOL/mPEG2000-DSPE (50:45:5 mol/mol) Lipid concentration: 20.0 mM Iroinotecan HCl: 2.0 mg/mL Encapsulation efficiency: > 95% (typically 98%) Loading battery: 250 mM ammonium sulfate Mean particle size: 100 nm (80-110 nm) External solution: 10% sucrose, 20 mM HEPES, pH 7.0 Shelf-life: 3 months, storage: 2-8 degree C F30204-TT-25STEALTH Liposomal Topotecan HCl (2.0mg/mL, 80-100nm) jPEGylated Liposomal Topotecan HCl Lipid composition: HSPC/CHOL/mPEG2000-DSPE (50:45:5 mol/mol) Lipid concentration: 20.0 mM Topotecan HCl: 2.0 mg/mL Encapsulation efficiency: > 95% Loading battery: 250 mM ammonium sulfate Mean particle size: 100 nm (80-110 nm) External solution: 10% sucrose, 20 Mm HEPES, pH 7.0 Shelf-life: 3 months, storage: 2-8 degree CFB30020Dilution Buffer for Doxoves 5Dilution Buffer for Doxoves This buffer dilution is made to match the bulk solution for most liposome encapsulated doxorubicin, Doxoves Composition: 10% sucrose, 10 mM histidine, pH 6.5 0.2 Volume: 50 mL Storage: sterile filtered (0.2m), store at 2-8 degree C Shelf-life: 6 months stored in refrigeratorF50101Cationic Liposomes DMTAP/DOPEDMTAP/DOPE Cationic Liposomes Lipid composition: DMTAP/DOPE (50:50 mol/mol) Mean particle size: 80-100 nm Lipid concentration: 5 mM (3.5 mg/mL) Bulk solution: DEPC water, 10% EthanolCationic LiposomesF50102Cationic Liposomes DOTAP/DOPEDOTAP/DOPE Cationic Liposomes Lipid composition: DOTAP/DOPE (50:50 mol/mol) Mean particle size: 80-100 nm Lipid concentration: 5 mM (3.61 mg/mL) Bulk solution: DEPC water, 10% EthanolF50103Cationic Liposomes DDAB/DOPEDDAB/DOPE Cationic Liposomes Lipid composition: DDAB/DOPE (50:50 mol/mol) Mean particle size: 80-100 nm Lipid concentration: 5 mM (3.44 mg/mL) Bulk solution: DEPC water, 10vol% ethanolF50104Cationic Liposomes DODAP/DOPEDODAP/DOPE Cationic Liposomes Lipid composition: DODAP/DOPE (50:50 mol/mol) Mean particle size: 80-100 nm Lipid concentration: 5 mM (3.48 mg/mL) Bulk solution: DEPC water, 10vol% ethanol Note: DODAP liposomes should be stored at 2-8 degree C at all times and used within one month.F50105Cationic Liposomes DC-CHOL/DOPEDC-CHOL/DOPE Cationic Liposomes Lipid composition: DC-CHOL/DOPE (30:70 mol/mol) Mean particle size: 80-100 nm Lipid concentration: 5 mM (3.41 mg/mL) Bulk solution: DEPC water, 10 vol% ethanol F60103-P3Placebo Control for fluorescent DOPC/CHOL Liposomes8Placebo Control DOP< C/CHOL Liposomes (100nm) Lipid composition: DOPC/CHOL (55:45 mol/mol) Lipid concentration: 50 mM (50-55 mM) Dye: no dye Mean particle size: 100 nm (85-110 nm) Hydration buffer: 10% sucrose, 20mM HEPES, pH 7.5 0.2 Storage: in refrigerator (2 - 8 degree C) Stability: 6 month for unopen vialsFluorescent Liposomes F60103F-D,DOPC/CHOL Liposomes labeled with dansyl DOPEuFluorescent DOPC/CHOL Liposomes Labeled with dansyl - DOPE (100nm) Lipid composition: DOPC/CHOL/Dansyl - DOPE (54:45:1 mol/mol) Lipid concentration: 50 mM (50-55 mM) Dansyl DOPE: 0.5 mM (0.50 mg/mL) Mean particle size: 100 nm (80-110 nm) Hydration buffer: 10% sucrose, 20mM HEPES, pH 7.5 0.2 Storage: in refrigerator (2 - 8 degree C) Stability: 6 month for unopened vials F60103F-F2 DOPC/CHOL Liposomes labeled with Fluorescein DHPEFluorescent DOPC/CHOL Liposomes labeled with Fluorescein DHPE (100nm) Lipid composition: DOPC/CHOL/ Fluorscein -DHPE (54:45:1 mol/mol) Lipid concentration: 50 mM (50-55 mM) Fluorscein DHPE: 0.5 mM (0.59 mg/mL) (excitation/emission maxima ~496/519 nm) Mean particle size: 100 nm (80-110 nm) Hydration buffer: 10% sucrose, 20mM HEPES, pH 7.5 0.2 Storage: in refrigerator (2 - 8 degree C) Stability: 6 month for unopened vials, protect from light F60103F-MB1DOPC/CHOL Liposomes labeled with Marina Blue-DHPEFluorescent DOPC/CHOL Liposomes Labeled with Marina Blue - DHPE (100nm) Lipid composition: DOPC/CHOL/MB-DHPE (54:45:1 mol/mol) Lipid concentration: 50 mM (50-55 mM) Marina Blue-DHPE: 0.5 mM (0.50 mg/mL) Ex/Em~365/460 nm Mean particle size: 100 nm (80-110 nm) Hydration buffer: 10% sucrose, 20mM HEPES, pH 7.5 0.2 Storage: in refrigerator (2 - 8 degree C) Stability: 6 month for unopened vials, protect from light F60103F-NBD'DOPC/CHOL Liposomes Labeled with NBD-PEFluorescent DOPC/CHOL Liposomes Labeled with NBD - PE (100nm) Lipid composition: DOPC/CHOL/NBD-PE (54:45:1 mol/mol) Lipid concentration: 50 mM (50-55 mM) NBD - PE: 0.5 mM (0.50 mg/mL) Ex/Em: ~463/536 nm Mean particle size: 100 nm (80-110 nm) Hydration buffer: 10% sucrose, 20mM HEPES, pH 7.3 0.2 Storage: in refrigerator (2 - 8 degree C) Stability: 6 month for unopened vials, protect from light F60103F-OG6DOPC/CHOL Liposomes labeled with Oregon Green 488 DHPEFluorescent DOPC/CHOL Liposomes labeled with Oregon Green 488 DHPE (100nm) Lipid composition: DOPC/CHOL/OG-DHPE (54:45:1 mol/mol) Lipid concentration: 50 mM (50-55 mM) Oregon Green 488 DHPE: 0.5 mM (0.54 mg/mL) Ex/Em: ~496/524 nm Mean particle size: 100 nm (85-110 nm) Hydration buffer: 10% sucrose, 20mM HEPES, pH 7.3 0.2 Storage: in refrigerator (2 - 8 degree C) Stability: 6 month for unopened vials, protect from light F60103F-R/DOPC/CHOL Liposomes labeled with Rhodamine DHPEFluorescent DOPC/CHOL Liposomes labeled with Rhodamine DHPE (100nm) Lipid composition: DSPC/CHOL/Rh-DHPE (54:45:1 mol/mol) Lipid concentration: 50 mM (50-55 mM) Rh-DHPE: 0.5mM (0.67mg/mL) Ex/Em: ~560/580 nm Mean particle size: 100 nm (85-110 nm) Hydration buffer: 10% sucrose, 20mM HEPES, pH 7.5 0.2 Storage: in refrigerator (2 - 8 degree C) Stability: 6 month for unopened vials, protect from light F60103F-TC+DOPC/CHOL Liposomes labeled with TRITC-DHPEFluorescent DOPC/CHOL Liposomes Labeled withTRITC - DHPE (100nm) Lipid composition: DOPC/CHOL/TC-DHPE (54:45:1 mol/mol) Lipid concentration: 50 mM (50-55 mM) TRITC - DHPE: 0.5 mM (0.62 mg/mL) Ex/Em: ~555/580 nm Mean particle size: 100 nm (80-110 nm) Hydration buffer: 10% sucrose, 20mM HEPES, pH 7.5 0.2 Storage: in refrigerator (2 - 8 degree C) Stability: 6 month for unopened vials, protect from light F60103F-TR/DOPC/CHOL Liposomes labeled with Texas Red DHPEFluorescent DOPC/CHOL Liposomes labeled with Texas Red 488 DHPE (100nm) Lipid composition: DOPC/CHOL/TR-DHPE (54:45:1 mol/mol) Lipid concentration: 50 mM (50-55 mM) Texas Red DHPE: 0.5 mM (0.54 mg/mL) Ex/Em: ~595/615 nm Mean particle size: 100 nm (85-110 nm) Hydration buffer: 10% sucrose, 20mM HEPES, pH 7.5 0.2 Storage: in refrigerator (2 - 8 degree C) Stability: 6 month for unopened vials, protect from light F60103F-DI$DOPC/CHOL Liposomes<  labeled with DiIFluorescent DOPC/CHOL Liposomes labeled with Dil (100nm) High quality LUV liposomes labeled with Dil are ready to use. The liposomes are prepared by the extrusion method to 100nm with very tight particle size distribution. The product is sterile filtered and filled in sterile vials guaranteed to be stable for 6 months when stored in refrigerator. Lipid composition: DOPC/CHOL (54:45 mol/mol) Lipid concentration: 50 mM (50-55 mM) DiI: 0.5mM (0.47mg/mL) Mean particle size: 100 nm (90-120 nm) Hydration buffer: 10% sucrose, 20mM HEPES, pH 7.3 0.2 Storage: in refrigerator (2 - 8 degree C) Shelf-life: 6 months guaranteed for unopened vials F60103F-DA$DOPC/CHOL Liposomes labeled with DiAuFluorescent DOPC/CHOL Liposomes labeled with DiA (100nm) High quality LUV liposomes labeled with DiA are ready to use. The liposomes are prepared by the extrusion method to 100nm with very tight particle size distribution. The product is sterile filtered and filled in sterile vials guaranteed to be stable for 6 months when stored in refrigerator. Lipid composition: DOPC/CHOL (54:45 mol/mol) Lipid concentration: 50 mM (50-55 mM) DiA: 0.5mM (0.39mg/mL) Mean particle size: 100 nm (90-120 nm) Hydration buffer: 10% sucrose, 20mM HEPES, pH 7.3 0.2 Storage: in refrigerator (2 - 8 degree C) Shelf-life: 6 month for unopen vials F60103F-DO-1$DOPC/CHOL Liposomes labeled with DiOFluorescent DOPC/CHOL Liposomes labeled with DiO (100nm) The fluorescent control liposomes contain the green lipophilic dye DiO incorporated in the bilayers. It is used for tracking the cellular uptake of the liposomes by common methods like confocal, FACS, etc. The green fluorescent, lipophilic carbocyanine DiOC18(3) is widely used as a lipophilic tracer. It is weakly fluorescent in water but highly fluorescent and quite photostable when incorporated into membranes. It has an extremely high extinction coefficient and short excited-state lifetimes (~1 nanosecond) in lipid environments. Lipid composition: DOPC/CHOL (54:45 mol/mol) Lipid concentration: 50 mM (50-55 mM) Mean particle size: 100 nm (90-120 nm) Hydration buffer: 10% sucrose, 20mM HEPES, pH 7.3 0.2 Dye: 0.5 mM (0.44 mg/mL) Stability: 6 months for unopened vials Storage: 2-8 C 'DiO'; DiOC18(3) (3,3'-Dioctadecyloxacarbocyanine Perchlorate) (Invitrogen D-275) Ex/Em: 484/501 nm F60103F-DR$DOPC/CHOL Liposomes labeled with DiRFluorescent DOPC/CHOL Liposomes labeled with DiR (100nm) The fluorescent liposomes contain the lipophilic Near IR dye DiR incorporated in the bilayers. It is used for tracking the cellular uptake of the liposomes in vitro and in vivo by common methods like confocal, FACS, NIR imaging etc. The near IR fluorescent, lipophilic carbocyanine DiOC18(7) ("DiR") is weakly fluorescent in water but highly fluorescent and quite photostable when incorporated into membranes. The sulfonate groups incorporated into this DiI analog improves water solubility. It has an extremely high extinction coefficient and short excited-state lifetimes (~1 nanosecond) in lipid environments. Lipid composition: DOPC/CHOL (54:45 mol/mol) Lipid concentration: 50 mM (50-55 mM) Mean particle size: 100 nm (90-120 nm) Hydration buffer: 10% sucrose, 20mM HEPES, pH 7.3 0.2 DiR: 0.5 mM (0.51mg/mL) Stability: 6 months for unopened vials Storage: 2-8 C 'DiR'; (Invitrogen D-12731) DiIC18(7) (1,1'-Dioctadecyl-3,3,3',3'-Tetramethylindotricarbocyanine Iodide) Ex/Em: 750/780 nm F60103F-DD$DOPC/CHOL Liposomes labeled with DiDFluorescent DOPC/CHOL Liposomes labeled with DiD (100nm) The fluorescent control liposomes contain the lipophilic dye DiD incorporated in the bilayers. It is used for tracking the cellular uptake of the liposomes by common methods like confocal, FACS, etc. The far-red fluorescent, lipophilic carbocyanine DiD is a longer-wavelength DiI analog. It is an oil at room temperature and weakly fluorescent in water but highly fluorescent and quite photostable when incorporated into membranes. It has an extremely high extinction coefficient and short excited-state lifetimes (~1 nanosecond) in lipid environm< ents. Lipid composition: DOPC/CHOL (54:45 mol/mol) Lipid concentration: 50 mM (50-55 mM) Mean particle size: 100 nm (90-120 nm) Hydration buffer: 10% sucrose, 20mM HEPES, pH 7.3 0.2 DiD: 0.5 mM (0.48mg/mL) Stability: 6 months for unopened vials Storage: 2-8 C 'DiD'; DiIC18(5) oil (1,1'-Dioctadecyl-3,3,3',3'-Tetramethylindodicarbocyanine Perchlorate) (Invitrogen D-307) Ex/Em: 644/665 nm F60203F-D6DOPC/CHOL/mPEG-DSPE Liposomes Labeled with Dansyl DOPEFluorescent DOPC/CHOL Liposomes Labeled with dansyl - DOPE (100nm) Lipid composition: DOPC/CHOL/mPEG2000-DSPE/Dansyl - DOPE (49:45:5:1 mol/mol) Lipid concentration: 50 mM (50-55 mM) Dansyl DOPE: 0.5 mM (0.50 mg/mL) Ex/Em: ~ 336D 517 nm Mean particle size: 100 nm (80-110 nm) Hydration buffer: 10% sucrose, 20mM HEPES, pH 7.3 0.2 Storage: in refrigerator (2 - 8 degree C) Stability: 6 month for unopened vials, protect from light F60203F-F< DOPC/CHOL/mPEG-DSPE Liposomes labeled with Fluorescein DHPEDOPC/CHOL/mPEG-DSPE Liposomes labeled with Fluorescein DHPE (100nm) Lipid composition: DOPC/CHOL/mPEG2000-DSPE/FITC-DHPE (49:45:5:1 mol/mol) Lipid concentration: 50 mM (50-55 mM) Fluorscein DHPE: 0.5mM (0.59 mg/mL) Ex/Em: ~496/519 nm Mean particle size: 100 nm (80-110 nm) Hydration buffer: 10% sucrose, 20mM HEPES, pH 7.5 0.2 Storage: in refrigerator (2 - 8 degree C) Stability: 6 month for unopened vials, protect from light F60203F-MB;DOPC/CHOL/mPEG-DSPE Liposomes labeled with Marina Blue-DHPEFluorescent DOPC/CHOL/mPEG2000-DSPE Liposomes Labeled with Marina Blue - DHPE (100nm) Product code: F60203F-MB Lipid composition: DOPC/CHOL/mPEG2000-DSPE/MB-DHPE (49:45:5:1 mol/mol) Lipid concentration: 50 mM (50-55 mM) Marina Blue - DHPE: 0.5 mM (0.50 mg/mL) Ex/Em: ~365/460 nm Mean particle size: 100 nm (80-110 nm) Hydration buffer: 10% sucrose, 20mM HEPES, pH 7.3 0.2 Storage: in refrigerator (2 - 8 degree C) Stability: 6 month for unopened vials, protect from light F60203F-NBD1DOPC/CHOL/mPEG-DSPE Liposomes Labeled with NBD-PEFluorescent DOPC/CHOL/mPEG2000-DSPE Liposomes Labeled with NBD - PE (100nm) Product code: F60203F-NBD Lipid composition: DOPC/CHOL/mPEG2000-DSPE/NBD-PE (49:45:5:1 mol/mol) Lipid concentration: 50 mM (50-55 mM) NBD -PE: 0.5 mM (0.50 mg/mL) Ex/Em: ~463/536 nm Mean particle size: 100 nm (80-110 nm) Hydration buffer: 10% sucrose, 20mM HEPES, pH 7.3 0.2 Storage: in refrigerator (2 - 8 degree C) Stability: 6 month for unopened vials, protect from light F60203F-OG@DOPC/CHOL/mPEG-DSPE Liposomes labeled with Oregon Green 488 DHPEFluorescent DOPC/CHOL/mPEG-DSPE Liposomes labeled with Oregon Green 488 DHPE (100nm) Lipid composition: DOPC/CHOL/mPEG-2000-DSPE/OG 488-DHPE (49:45:5:1 mol/mol) Lipid concentration: 50 mM (50-55 mM) Oregon Green 488 DHPE: 0.5mM (0.54 mg/mL) Ex/Em: ~496/524 nm Mean particle size: 100 nm (85-110 nm) Hydration buffer: 10% sucrose, 20mM HEPES, pH 7.3 0.2 Storage: in refrigerator (2 - 8 degree C) Stability: 6 month for unopened vials, protect from light F60203F-R=DOPC/CHOL/mPEG2000-DSPE Liposomes labeled with Rhodamine DHPEFluorescent DOPC/CHOL/mPEG2000-DSPE Liposomes labeled with Rhodamine DHPE (100nm) Lipid composition: DOPC/CHOL/mPEG2000-DSPE/Rh-DHPE (49:45:5:1 mol/mol) Lipid concentration: 50 mM (50-55 mM) Rhodamine -DHPE: 0.5 mM (0.67mg/mL) Ex/Em: ~560/580 nm Mean particle size: 100 nm (85-110 nm) Hydration buffer: 10% sucrose, 20mM HEPES, pH 7.3 0.2 Storage: in refrigerator (2 - 8 degree C) Stability: 6 month for unopened vials, protect from light F60203F-TC5DOPC/CHOL/mPEG-DSPE Liposomes labeled with TRITC-DHPEFluorescent DOPC/CHOL/mPEG2000-DSPE Liposomes Labeled with TRITC - DHPE (100nm) Lipid composition: DOPC/CHOL/mPEG2000-DSPE/TC-DHPE (49:45:5:1 mol/mol) Lipid concentration: 50 mM (50-55 mM) TRITC - DHPE: 0.5 mM (0.62 mg/mL) Ex/Em: ~555/580 nm Mean particle size: 100 nm (80-110 nm) Hydration buffer: 10% sucrose, 20mM HEPES, pH 7.3 0.2 Storage: in refrigerator (2 - 8 degree C) Stability: 6 month for unopened vials, protect from light F60203F-TR9DOPC/CHOL/mPEG-DSPE Liposomes labeled with Texas Red DHPEFluorescent DOPC/CHOL/mPEG-DS< PE Liposomes labeled with Texa Red 488 DHPE (100nm) Lipid composition: DOPC/CHOL/mPEG2000-DSPE/TR-DHPE (49:45:5:1 mol/mol) Lipid concentration: 50 mM (50-55 mM) Texas Red DHPE: 0.5mM (0.54 mg/mL) Ex/Em: ~595/615 nm Mean particle size: 100 nm (85-110 nm) Hydration buffer: 10% sucrose, 20mM HEPES, pH 7.3 0.2 Storage: in refrigerator (2 - 8 degree C) Stability: 6 month for unopened vials, protect from lightF60203-P,Placebo Control DOPC/CHOL/PEG-DSPE LiposomesTPlacebo Control DOPC/CHOL/PEG2000-DSPE Liposomes (100nm) Lipid composition: DSPC/CHOL/PEG2000-DSPE (55:45 mol/mol) Lipid concentration: 50 mM (50-55 mM) Dye: no dye Mean particle size: 100 nm (85-110 nm) Hydration buffer: 10% sucrose, 20mM HEPES, pH 7.3 0.2 Storage: in refrigerator (2 - 8 degree C) Stability: 6 month for unopened vials F60203F-DD6PEGylated DOPC/CHOL/mPEG-PE Liposomes labeled with DiD*Fluorescent DOPC/CHOL/mPEG-DSPE Liposomes labeled with DiD (100nm) The fluorescent control liposomes contain the lipophilic dye DiD incorporated in the bilayers. It is used for tracking the cellular uptake of the liposomes by common methods like confocal, FACS, etc. The far-red fluorescent, lipophilic carbocyanine DiD is a longer-wavelength DiI analog. It is an oil at room temperature and weakly fluorescent in water but highly fluorescent and quite photostable when incorporated into membranes. It has an extremely high extinction coefficient and short excited-state lifetimes (~1 nanosecond) in lipid environments. Lipid composition: DOPC/CHOL/mPEG-2000-DSPE (50:45:5 mol/mol) Lipid concentration: 50 mM (50-55 mM) Lipid concentration: 50 mM (50-55 mM) Mean particle size: 100 nm (85-110 nm) Hydration buffer: 10% sucrose, 20mM HEPES, pH 7.3 0.2 DiD: 0.5 mM (0.48mg/mL) Stability: 6 months for unopened vials Storage: 2-8 C 'DiD'; DiIC18(5) oil (1,1'-Dioctadecyl-3,3,3',3'-Tetramethylindodicarbocyanine Perchlorate) (Invitrogen D-307) Ex/Em: 644/665 nm F60203F-DA.PEGylated DOPC/CHOL Liposomes labeled with DiAFluorescent DOPC/CHOL Liposomes labeled with DiA (100nm) High quality LUV liposomes labeled with DiA are ready to use. The liposomes are prepared by the extrusion method to 100nm with very tight particle size distribution. The product is sterile filtered and filled in sterile vials guaranteed to be stable for 6 months when stored in refrigerator. Lipid composition: DOPC/CHOL/mPEG-DSPE (50:45:5 mol/mol) Lipid concentration: 50 mM (50-55 mM) DiA: 0.5mM (0.39mg/mL) Mean particle size: 100 nm (85-110 nm) Hydration buffer: 10% sucrose, 20mM HEPES, pH 7.3 0.2 Storage: in refrigerator (2 - 8 degree C) Shelf-life: 6 month for unopen vials 'DiA'; (Invitrogen D-3883) 4-Di-16-ASP (4-(4-(Dihexadecylamino)styryl)-N-Methylpyridinium Iodide) Ex/Em: 456/590 nm F60203F-DI.PEGylated DOPC/CHOL Liposomes labeled with DiIFluorescent DOPC/CHOL/mPEG-DSPE Liposomes labeled with Dil (100nm) High quality LUV liposomes labeled with Dil are ready to use. The liposomes are prepared by the extrusion method to 100nm with very tight particle size distribution. The product is sterile filtered and filled in sterile vials guaranteed to be stable for 6 months when stored in refrigerator. Lipid composition: DOPC/CHOL/mPEG2000-DSPE (50:45:5 mol/mol) Lipid concentration: 50 mM (50-55 mM) DiI: 0.5mM (0.47mg/mL) Mean particle size: 100 nm (85-110 nm) Hydration buffer: 10% sucrose, 20mM HEPES, pH 7.3 0.2 Storage: in refrigerator (2 - 8 degree C) Shelf-life: 6 months guaranteed for unopened vials DiI; DiIC18(3) (Invitrogen V22889) is a lipophilic membrane dye. It is weakly fluorescent until incorporated into liposome membranes. This orange red-fluorescent dye, which is spectrally similar to tetramethylrhodamine, is often used as a long-term tracer for neuronal and other cells. Ex/Em: 550nm/570nm F60203F-DR.PEGylated DOPC/CHOL Liposomes labeled with DiR8Fluorescent DOPC/CHOL/mPEG-DSPE Liposomes labeled with DiR (100nm) The fluorescent liposomes contain the lipophilic Near IR dye DiR incorporated in the bilayers. It is used for tracking the cellular uptake of the liposomes in vitro and in vivo by common m< ethods like confocal, FACS, NIR imaging etc. The near IR fluorescent, lipophilic carbocyanine DiOC18(7) ("DiR") is weakly fluorescent in water but highly fluorescent and quite photostable when incorporated into membranes. The sulfonate groups incorporated into this DiI analog improves water solubility. It has an extremely high extinction coefficient and short excited-state lifetimes (~1 nanosecond) in lipid environments. Lipid composition: DOPC/CHOL/mPEG2000-DSPE (50:45:5 mol/mol) Lipid concentration: 50 mM (50-55 mM) Mean particle size: 100 nm (85-110 nm) Hydration buffer: 10% sucrose, 20mM HEPES, pH 7.3 0.2 DiR: 0.5 mM (0.51mg/mL) Stability: 6 months for unopened vials Storage: 2-8 C 'DiR'; (Invitrogen D-12731) DiIC18(7) (1,1'-Dioctadecyl-3,3,3',3'-Tetramethylindotricarbocyanine Iodide) Ex/Em: 750/780 nm F60203F-DO.PEGylated DOPC/CHOL Liposomes labeled with DiOFluorescent DOPC/CHOL Liposomes labeled with DiO (100nm) The fluorescent liposomes contain the green lipophilic dye DiO incorporated in the bilayers. It is used for tracking the cellular uptake of the liposomes by common methods like confocal, FACS, etc. The green fluorescent, lipophilic carbocyanine DiOC18(3) is widely used as a lipophilic tracer. It is weakly fluorescent in water but highly fluorescent and quite photostable when incorporated into membranes. It has an extremely high extinction coefficient and short excited-state lifetimes (~1 nanosecond) in lipid environments. Lipid composition: DOPC/CHOL/mPEG2000-DSPE (50:45;5 mol/mol) Lipid concentration: 50 mM (50-55 mM) Mean particle size: 100 nm (85-110 nm) Hydration buffer: 10% sucrose, 20mM HEPES, pH 7.3 0.2 Dye: 0.5 mM (0.44 mg/mL) Stability: 6 months for unopened vials Storage: 2-8 C 'DiO'; DiOC18(3) (3,3'-Dioctadecyloxacarbocyanine Perchlorate) (Invitrogen D-275) Ex/Em: 484/501 nm F60103F2-PFPlacebo Control DOPC/CHOL Liposomes (200nm) for Fluorescent liposomesCPlacebo Control DOPC/CHOL Liposomes (200nm) Lipid composition: DOPC/CHOL (55:45 mol/mol) Lipid concentration: 50 mM (50-55 mM) Dye: no dye Mean particle size: 230 nm (200-250 nm, intensity weighted lognormal per DSL) Particle size distribution: 80-100nm (half-width) Hydration buffer: 10% sucrose, 20mM HEPES, pH 7.5 0.2 F60103F2-FEFluorescent DOPC/CHOL Liposomes labeled with Fluorescein DHPE (200nm)Fluorescent DOPC/CHOL Liposomes labeled with Fluorescein DHPE (200nm) High quality LUV liposomes labeled with fluorescein DHPE are ready to use. The liposomes are prepared by the extrusion technology to 200-250nm nm with tight particle size distribution. The product is semisterile filtered through 0.45um filters and filled in autoclaved vials guaranteed to be stable for 3 months stored in refrigerator. The phospholipid, fluorescein DHPE is labeled on the head group with the green-fluorescent pH-sensitive fluorophore, fluorescein (excitation/emission maxima ~496/519 nm). Lipid composition: DOPC/CHOL/Fluorescein-DHPE (54:45:1 mol/mol) Lipid concentration: 50 mM (50-55 mM) Fluorscein DHPE: 0.5 mM (0.59 mg/mL) Mean particle size: 230 nm (200-250 nm, intensity weighted lognormal per DSL) Particle size distribution: 80-100nm (half-width) Hydration buffer: 10% sucrose, 20mM HEPES, pH 7.5 0.2 Storage: in refrigerator (2 - 8 degree C) Shelf-life: 3 month for unopened vials, protect from light F60103F2-RCFluorescent DOPC/CHOL Liposomes labeled with Rhodamine DHPE (200nm)Fluorescent DOPC/CHOL Liposomes labeled with Rhodamine DHPE (200nm) High quality LUV liposomes labeled with Rhodamine DHPE (Rh-DHPE) are ready to use. The liposomes are prepared by extrusion to 200-250nm with tight particle size distribution. The product is sterile filtered through 0.45um filters and filled in sterile vials guaranteed for 3 months shelf-life properly stored in refrigerator. Rh--DHPE is a phospholipid labeled on the head group with the red-fluorescent rhodamine B fluorophore with excitation/emission maxima ~560/580 nm. For more information on the dye, see Invitrogen L-1392. Specifications Product code: F60103F2-R Lipid composition: DOPC/CHOL/Rh-DHPE (54:4< 5:1 mol/mol) Lipid concentration: 50 mM (50-55 mM) Rh-DHPE: 0.5mM (0.67mg/mL) Mean particle size: 230 nm (200-250 nm, intensity weighted lognormal per DSL) Particle size distribution: 80-100nm (half-width) Hydration buffer: 10% sucrose, 20mM HEPES, pH 7.5 0.2 Storage: in refrigerator (2 - 8 degree C) Shelf-life: 3 month for unopened vials, protect from light F60103F2-TRHFluorescent DOPC/CHOL Liposomes labeled with Texas Red 488 DHPE (200nm)-Fluorescent DOPC/CHOL Liposomes labeled with Texas Red 488 DHPE (200nm) High quality LUV liposomes labeled with Texas Red DHPE (TR-DHPE) are ready to use. The liposomes are prepared by the extrusion technology to 200-250nm with very tight particle size distribution. The product is sterile filtered through 0.45um and filled in sterile vials guaranteed to be stable for 3 months when stored in refrigerator. The phospholipid, Texas Red 1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine, triethylammonium salt (Texas Red DHPE) is labeled on the head group with the bright, red-fluorescent Texas Red dye (excitation/emission maxima ~595/615 nm). Lipid composition: DOPC/CHOL/TR-DHPE (54:45:1 mol/mol) Lipid concentration: 50 mM (50-55 mM) Texas Red DHPE: 0.5 mM (0.54 mg/mL) Mean particle size: 230 nm (200-250 nm, intensity weighted lognormal per DSL) Particle size distribution: 80-100nm (half-width) Hydration buffer: 10% sucrose, 20mM HEPES, pH 7.3 0.2 Storage: in refrigerator (2 - 8 degree C) Shelf-life: 3 month for unopened vials, protect from light F70101C-NASFEvaluation Samples: Clophosome (neutral) and Clophosome-A (anionic)USAEvaluation samples: Clophosome and Clophosome - A This kit consists one of both of the following items 1 vial (1 mL ) of Clophosome - clodronate liposomes (F70101C-N) 1 vial (1 mL ) of Clophosome-A - clodronate liposomes (F70101C-A) You pay for the shipping only"Clophosome - Clodronate Liposomes F70101C-N-2+Clophosome, Clodronate Liposomes (Neutral)3Clophosome, neutral clodronate liposomes, offers highly efficient in vivo macrophage depletion. Clodronate molecules are encapsulated in small MLV liposomes for superior activity, physical and chemical stability, and convenience of use. It is formulated to an exceptionally high clodronate/lipid ratio. Free clodronate is cleaned out and the liposomal clodronate encapsulation efficiency is more than 90%. Clophosome liposomes remain homogenous and suspended even after long term storage in fridge. It is not viscous and easy to inject. It is manufactured sterile for long term shelf-life. The product is suitable for dosing with various routes including intravenous, intraperitoneal, subcutaneous, intranasal, intratracheal and etc. We have achieved 80-90% macrophage depletion in spleen (red pulp macrophages) 24 hours after a single 0.2 mL intravenous injection. A starting dose of 0.15 - 0.2 mL (i.v. or i.p.) for 20-25g animal body weight is recommended for good consistency in macrophage depletion. Optimization is recommended for your specific applications. Active: clodronate disodium. CAS: 22560-50-5, 7 mg/mL Lipid composition: phosphatidylcholine and cholesterol Bulk solution: phosphate buffered saline (20mM sodium phosphate, 0.9% NaCl), pH 7.0-7.5 Shelf-life: 6 months guaranteed for unopened vials, do not freeze F70101C-N-10 F70101-N-21Plain Control Liposomes for Clophosome (Neutral)Plain Control Liposomes for Clophosome (Neutral) This product of empty liposomes are made to match the physical and chemical attributes of Clophosome without the active clodronate encapsulated. It should be used as a negative control for macrophage depletion studies. Lipid composition: phosphatidylcholine and cholesterol Clodronate concentration: None Bulk solution: phosphate buffered saline (20mM sodium phosphate, 0.9% NaCl), pH 7.0-7.5 Storage and Stability: stable for 6 months when stored in refrigerator (2-8 degree C). F70101-N-10 F70101F-N-27Fluorescent Control Liposomes for Clophosome (neutral)Fluorescent Control Liposomes for Clophosome (Neutral) The fluorescent control liposomes contain the lipophilic dy< e Dil incorporated in the bilayers. It has comparable physical and chemical attributes as for the Clophosome except no active is encapsulated inside. It is used for tracking the cellular uptake of the liposomes by common methods like confocal, FACS, etc. Lipid composition: phosphatidylcholine and cholesterol Dye: 0.15 mM (0.14mg/mL) Stability: 6 months for unopened vials F70101F-N-10 F70101C-NC-24Combo: Clophosome-N (neutral) and Control LiposomesCombo: Clophosome and Control Liposomes Combo (neutral) This kit consists of the following items 1 vial (2 or 10mL) of Clophosome - clodronate liposomes (F70101C-N) 1 vial (2 or 10mL) of control plain liposomes (F70101-N) F70101C-NC-10 F70101C-NF-2FCombo: Clophosome-N (neutrral), Fluorescent & Plain Control Liposomes-Combo: Clophosome and the Fluorescent and Control Liposomes (Neutral) This kit consists of the following items 1 vial (2 or 10mL) of Clophosome - clodronate liposomes (F70101C-N) 1 vial (2 or 10mL) of fluorescent control liposomes (F70101N-F) 1 vial (2 or 10mL) of control plain liposomes (F70101-N) F70101C-NF-10 F70101C-A-2.Clophosome-A - Clodronate Liposomes (Anionic)Clophosome-A- Clodronate Liposomes (Anionic) Clophosome-A, negatively-charged clodronate liposomes, offers superior efficiency of macrophage depletion. Clodronate molecules are encapsulated in LUV liposomes for superior activity, physical and chemical stability, and convenience of use. It is formulated to an exceptionally high clodronate/lipid ratio. Free clodronate is cleaned out and the liposomal encapsulation efficiency of clodronate is more than 90%. Clophosome liposomes remain homogenous even after long term storage in fridge. It is not viscous and easy to inject even with fine needles. It is manufactured sterile for long term shelf-life. The product is suitable for dosing with various routes including intravenous, intraperitoneal, subcutaneous, intranasal, intratracheal and etc. We have achieved > 90% depletion in splenic macrophages (red pulp macrophages) 24 hours after a single 0.2 mL intravenous injection. A starting dose of 0.15-2 mL (i.v. or i.p.) for 20-25g animal body weight is recommended for good consistency in macrophage depletion. Optimization is recommended for specific applications. Product name: Clophosome-A Active: clodronat disodium. CAS: 22560-50-5, 7 mg/mL Lipid composition: phosphatidylglycerol, phosphatidylcholine and cholesterol Bulk solution: phosphate buffered saline (20mM sodium phosphate, 0.9% NaCl), pH 7.0-7.5 Shelf-life: 6 months for unopened vials, do not freeze F70101C-A-10 F70101-A-23Plain Control Liposomes for Clophosome-A (Anionic)+Plain Control Liposomes for Clophosome-A (Anionic) This product of empty liposomes are made to match the physical and chemical attributes of Clophosome-A without the active clodronate encapsulated. It should be used as a negative control for macrophage depletion studies. Lipid composition: phosphatidylcholine, phosphatidylglycerol and cholesterol Clodronate concentration: None Bulk solution: phosphate buffered saline (20mM sodium phosphate, 0.9% NaCl), pH 7.0-7.5 Storage and Stability: stable for 6 months when stored in refrigerator (2-8 degree C) F70101-A-10 F70101F-A-29Fluorescent Control Liposomes for Clophosome-A (anionic)Fluorescent Control Liposomes for Clophosome-A (Anionic) The fluorescent control liposomes contain the lipophilic dye Dil incorporated in the bilayers. It has comparable physical and chemical attributes as for the Clophosome - A except no active is encapsulated inside. It is used for tracking the cellular uptake of the liposomes by common methods like confocal, FACS, etc. Lipid composition: phosphatidylcholine, phosphatidylglycerol and cholesterol Dye: 0.15 mM (0.14mg/mL) Bulk solution: phosphate buffered saline (20mM sodium phosphate, 0.9% NaCl), pH 7.0-7.5 Storage and Stability: stable for 6 months when stored in refrigerator (2-8 degree C) F70101F-A-10 F70101C-AC-2*Combo: Clophosome-A and Control LiposomesCombo: Clophosome-A and Control Liposomes This kit consists of the following<  items 1 vial (2 or 10mL) of Clophosome-A - anionic clodronate liposomes (F70101C-A) 1 vial (2 or 10mL) of control anionic liposomes (F70101-A) F70101C-AC-10 F70101C-AF-24Clophosome-A, Fluorescent & Plain Control Liposomes2Combo: Clophosome - A, the Fluorescent liposomes and the Control Liposomes This kit consists of the following items 1 vial (2 or 10mL) of Clophosome - clodronate liposomes (F70101C-A) 1 vial (2 or 10mL) of fluorescent control liposomes (F70101F-A) 1 vial (2 or 10mL) of control plain liposomes (F70101-A) F70101C-AF-10 F70101C-NA-2hAll-In-One Combo Kit: Clophosome-A (anionic), Clophosome-N (neutral) - And Control Liposomes for bothbCombo: Clophosome and Clophosome-A And Control Liposomes This all-in-one set is an excellent choice if you want to evaluate and compare the two clodronate liposome products. Included in this kit are one vial of each of the two clodronate liposomes and their plain control liposomes. This kit consists of the following items 1 vial (2 mL or 10 mL) of Clophosome - clodronate liposomes (F70101C-N) 1 vial (2 mL or 10 mL) of Clophosome-A - Anionic clodronate liposomes (F70101C-A) 1 vial (2 mL or 10 mL) of neutral control liposomes (F70101-N) 1 vial (2 mL or 10 mL) of anionic control liposomes (F70101-A) F70101C-NA-10 F70101C-NH JHigh Potency Clophosome- Clodronate Liposomes (Neutral, 1.0 mL, 20 mg/mL)tHigh Potency Clophosome- Clodronate Liposomes (Neutral, 1.0 mL, 20 mg/mL) High potency Clophosome is created to satisfy the demand for small volume dosing of concentrated clodronate liposomes through routes that are not amendable for large volume injection, such as intratracheal or intranasal, ICV, or intra-tumor injection. Please note this product has not been fully evaluated for any dosing approaches. Customers are strongly recommended to conduct their own studies to determine the appropriate dose regimen for their experiments. Active: clodronate disodium. CAS: 22560-50-5 Clodronate disodium: 20 mg/mL Volume: 1.0mLF1N5119,Polycarbonate Membrane Filter (19mm, 0.05um)&Polycarbonate Membrane Filter (19mm, 0.05um) This polycarbonate Track Etch (PCTE) membrane is ideally suited for use as the last extrusion membrane for making 75-85 nm liposomes. Pore size (um): 0.05 Size (mm): 19 Pack Size: 100 Color: white transluscent Thickness: 25um Minimum order: 5 boxes19mm, Extrusion membranes F1N8119,Polycarbonate Membrane Filter (19mm, 0.08um)Polycarbonate Membrane Filter (19mm, 0.08um) This polycarbonate Track Etch (PCTE) membrane is ideally suited for use as the last extrusion membrane for making 80nm liposomes. Pore size (um): 0.08 Size (mm): 19 Pack Size: 100 Color: white transluscent Min order: 519mm Extrusion membranesF1N10119+Polycarbonate Membrane Filter (19mm, 0.1um) Polycarbonate Membrane Filter (19mm, 0.1um) This polycarbonate Track Etch (PCTE) membrane is ideally suited for use as the last extrusion membrane for making 100-120 nm liposomes. Pore size (um): 0.1 Size (mm): 19 Pack Size: 100 Color: white transluscent Min order: 5F1N20119+Polycarbonate Membrane Filter (19mm, 0.2um)HPolycarbonate Membrane Filter (19mm, 0.2um) This polycarbonate Track Etch (PCTE) membrane is ideally suited for use as the last extrusion membrane for making 200 nm liposomes or as an intermadiate membrane in a step-wise extrusion process. Pore size (um): 0.2 Size (mm): 19 Pack Size: 100 Color: white transluscent Min order: 5F1N40119+Polycarbonate Membrane Filter (25mm, 0.4um)HPolycarbonate Membrane Filter (25mm, 0.4um) This polycarbonate Track Etch (PCTE) membrane is ideally suited for use as the last extrusion membrane for making 400 nm liposomes or as an intermadiate membrane in a step-wise extrusion process. Pore size (um): 0.4 Size (mm): 19 Pack Size: 100 Color: white transluscent Min order: 5F1M10119,Polycarbonate Membrane Filter (19mm, 1.0 um)Polycarbonate Membrane Filter (19mm, 1.0 um) This polycarbonate Track Etch (PCTE) membrane is ideally suited for use as the fisrt membrane in a step-wise extrusion process. Pore size (um): 1.0 Size (mm): 19 Pack Size: 100 Colo<+r: white transluscent Min order: 5F1N5125,Polycarbonate Membrane Filter (25mm, 0.05um) Polycarbonate Membrane Filter (25mm, 0.05um) This polycarbonate Track Etch (PCTE) membrane is ideally suited for use as the last extrusion membrane for making 75-90 nm liposomes. Pore size (um): 0.05 Size (mm): 25 Pack Size: 100 Color: white transluscent Min order: 1F1N8125,Polycarbonate Membrane Filter (25mm, 0.08um) Polycarbonate Membrane Filter (25mm, 0.08um) This polycarbonate Track Etch (PCTE) membrane is ideally suited for use as the last extrusion membrane for making 80-90nm liposomes. Pore size (um): 0.08 Size (mm): 25 Pack Size: 100 Color: white transluscent Min order: 525mm Extrusion membranesF1N10125+Polycarbonate Membrane Filter (25mm, 0.1um) Polycarbonate Membrane Filter (25mm, 0.1um) This polycarbonate Track Etch (PCTE) membrane is ideally suited for use as the last extrusion membrane for making 100-120 nm liposomes. Pore size (um): 0.1 Size (mm): 25 Pack Size: 100 Color: white transluscent Min order: 5F1N20125+Polycarbonate Membrane Filter (25mm, 0.2um)HPolycarbonate Membrane Filter (25mm, 0.2um) This polycarbonate Track Etch (PCTE) membrane is ideally suited for use as the last extrusion membrane for making 200 nm liposomes or as an intermadiate membrane in a step-wise extrusion process. Pore size (um): 0.2 Size (mm): 25 Pack Size: 100 Color: white transluscent Min order: 1F1N40125HPolycarbonate Membrane Filter (25mm, 0.4um) This polycarbonate Track Etch (PCTE) membrane is ideally suited for use as the last extrusion membrane for making 400 nm liposomes or as an intermadiate membrane in a step-wise extrusion process. Pore size (um): 0.4 Size (mm): 25 Pack Size: 100 Color: white transluscent Min order: 1F1M10125,Polycarbonate Membrane Filter (25mm, 1.0 um)Polycarbonate Membrane Filter (25mm, 1.0 um) This polycarbonate Track Etch (PCTE) membrane is ideally suited for use as the fisrt membrane in a step-wise extrusion process. Pore size (um): 1.0 Size (mm): 25 Pack Size: 100 Color: white transluscent Min order: 1A8 a    m%O-  dMbP?_*+%&ffffff?'ffffff?(?)?" d333333?333333?& U} @}  A}  A} @ B} `A} [A} A}  Am@    FFTF F F F F FFTTTbTb~ ~ pp88  **pC D D D D D DC E EE?E"@ F E G E EE?Ej@ F E G E E E ~ E4@ F E G E E~ E@E@2 F E C E EE$@E@ F EC E EE$@E-@ F EC E EE$@E۳@ F EC E EE$@E@ F E C E E E$@E׷@ F E C E! E" E$@Eӻ@ F# E C E$ E% E$@E:@ F& E C E' E( E$@Eӻ@ F) E C E* E+ E$@E+@ F, EC E- E.E$@E:@ F/ EC E0 E1E$@E@ F2 E3C E4 E5E$@E@ F6 E3C E7 E8E$@E@ F9 E3C E: E;E$@E:@ F< E3C E= E>E$@E@ F? 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